If you add enough purigen I imagine it's possible to starve off some of your BB, but it's going to be really tough to get rid of all of it. That said, it might be one of those things where once you go on it, you really can't easily go off it, depending on how much of the stuff you're using.
I have 2 tanks where nitrates have consistently been 40ppm - 80ppm despite regular large water changes. The best way to fix this problem would be to tear both tanks down, pull the substrate out, and thoroughly clean it before reassembling the tank. That, unfortunately, is just not practical without getting rid of a ton of plants, fish, and inverts. The next best thing is something to sequester some of the organics before they can be processed into nitrates, I think. We'll see
I had a couple of big plant die-offs in this tank so there's a lot of organics that are being continually processed in there.